Apotex Pharmachem Pharmaceutical Purity Ingredients Distributor CAS numbers MSDS
Reagent-Free Colorimetric Assay for Galactose Utilizing Agarose Gel Entrapping Nanoceria
Desloratadine, a Novel Antigrowth Reagent for Bladder Most cancers.
Desloratadine, a potent antagonist for human histamine H1 receptor, has been revealed to exhibit antihistaminic exercise and anti inflammatory exercise. Nonetheless, it isn’t but recognized whether or not desloratadine has any impact on the organic behaviors of tumor cells. On this research, we aimed to research the results of desloratadine on cell development and invasion in bladder most cancers EJ and SW780 cells in vitro.
We noticed that desloratadine inhibited cell viability of EJ and SW780 cells in a dose- and time-dependent method. Desloratadine remedy was additionally revealed to suppress colony-formation capacity and induce cell cycle arrest at G1 section in EJ cells. Desloratadine promoted cell apoptosis through modulating the expression of Bcl-2, Bax, cleaved caspase 3, and cleaved caspase 9 in EJ and SW780 cells.
Western blot resulted confirmed that desloratadine additionally impaired the expression of autophagy-related proteins, reminiscent of Beclin 1, P62, and LC3I/II in EJ and SW780 cells; whereas autophagy inhibitor LY294002 reversed the results of desloratadine on these proteins.
Furthermore, desloratadine remarkably attenuated cell migration and invasion. Moreover, we illustrated that desloratadine downregulated the expression of N-cadherin, Vimentin, Snail1, and Snail2, whereas upregulated the expression of E-cadherin in EJ and SW780 cells in vitro.
The extent of interleukin 6 was diminished in desloratadine-treated cells, whereas upregulation of interleukin 6 considerably abolished the anticancer exercise of desloratadine in cell invasion and Bcl-2, Bax, Beclin1, LC3-I/II, N-cadherin, and E-cadherin expression in EJ cells.
Taken collectively, our knowledge recommend a possible anticancer exercise of desloratadine on cell development and invasion for bladder most cancers, which can be mediated by diminishing the epithelial-to-mesenchymal transition and interleukin 6.
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:10-1:50
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000
Description: A polyclonal antibody against HMGB1. Recognizes HMGB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000
Description: The high-mobility group box 1 (HMGB1) protein was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression (1,2). However, HMGB1 has more recently emerged as an extracellularly released mediator of inflammation and repair responses in lipopolysaccharide (LPS)-induced endotoxemia and sepsis (3). HMGB1 has also been suggested to induce secretion of pro-inflammatory cytokines and chemokines by inducing NF-kB signaling downstream of Toll-like receptor (TLR) 2 and TLR4 activation (4).
Description: The high-mobility group box 1 (HMGB1) protein was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression (1,2). However, HMGB1 has more recently emerged as an extracellularly released mediator of inflammation and repair responses in lipopolysaccharide (LPS)-induced endotoxemia and sepsis (3). HMGB1 has also been suggested to induce secretion of pro-inflammatory cytokines and chemokines by inducing NF-kB signaling downstream of Toll-like receptor (TLR) 2 and TLR4 activation (4).
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is unconjugated.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 390.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 488.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 565.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 594.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 633.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 655.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 680.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to ATTO 700.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Alkaline Phosphatase.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to APC .
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to APC/Cy7.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Biotin.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Dylight 350.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Dylight 405.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Dylight 488.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Dylight 594.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Dylight 633.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to FITC.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to HRP.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to PE/ATTO 594.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to PerCP.
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to RPE .
Description: A polyclonal antibody for HMGB1 from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human HMGB1.. The Antibody is tested and validated for WB, ELISA assays with the following recommended dilutions: WB (1:1000), ELISA (1:20000). This HMGB1 antibody is conjugated to Streptavidin.
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of HMGB-1 in human serum, plasma and other biological fluids
Reagent-Free Colorimetric Assay for Galactose Utilizing Agarose Gel Entrapping Nanoceria and Galactose Oxidase.
A reagent-free colorimetric technique for galactose quantification utilizing a composite of cerium oxide nanoparticles (nanoceria) and galactose oxidase (Gal Ox) entrapped in an agarose gel was developed. Within the presence of galactose, the Gal Ox entrapped inside the agarose gel catalyzed the oxidation of galactose to generate H2O2, which induced a shade change from white to intense yellow.
This response occurred with none chromogenic substrate. This shade transition is presumed to be as a result of H2O2-mediated alteration of the oxidation state of cerium ions current on the floor of the nanoceria.
The depth of shade change was quantified by buying a picture with a traditional smartphone, changing the picture to cyan-magenta-yellow-black (CMYK) mode, and subsequently analyzing the picture utilizing the ImageJ software program.
Utilizing this technique, galactose focus was particularly decided with wonderful sensitivity of as little as 0.05 mM. The analytical utility of the assay was efficiently verified by appropriately figuring out various ranges of galactose in human serum, which is sufficient to diagnose galactosemia, a genetic dysfunction characterised by the malfunctioning of enzymes liable for galactose metabolism.
The assay using a hydrogel composite with entrapped nanoceria and Gal Ox, is an easy, cost-effective, and speedy colorimetric assay for galactose quantification, with out utilizing any chromogenic reagent. This cost-effective technique has nice potential for the analysis of galactosemia and is very promising compared to the laborious instrumentation-based strategies at the moment in use.
Uneven copper-catalyzed conjugate additions of organometallic reagents within the syntheses of pure compounds and prescribed drugs.
Entry to enantiopure complicated molecular constructions is essential for the event of latest medicine in addition to brokers utilized in crop-protection. On this regard, quite a few uneven strategies have been established. Copper-catalyzed 1,4-additions of organometallic reagents are strong C-C bond formation methods relevant in a variety of circumstances.
This evaluation analyses the syntheses of pure merchandise and pharmaceutical brokers, which depend on the appliance of uneven Cu-catalyzed conjugate additions of assorted organometallic reagents. A variety of accessible organometallics, e.g. dialkylzinc, trialkylaluminum, Grignard, and organozirconium, can now be utilized in conjugate additions to deal with numerous artificial challenges current in focused pure compounds. Moreover, environment friendly catalysts permit excessive ranges of stereofidelity over a various array of beginning Michael acceptors.
Description: Quantitativesandwich ELISA kit for measuring Human CD97 antigen (CD97) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human CD97 antigen(CD97) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A polyclonal antibody against CD97. Recognizes CD97 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Description: A polyclonal antibody against CD97. Recognizes CD97 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC
Description: A polyclonal antibody against CD97. Recognizes CD97 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Description: A polyclonal antibody against CD97. Recognizes CD97 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100
Description: A competitive ELISA for quantitative measurement of Human CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD97 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: A polyclonal antibody against Cleaved-CD97 (L530). Recognizes Cleaved-CD97 (L530) from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000
Description: A polyclonal antibody against Cleaved-CD97 (S531). Recognizes Cleaved-CD97 (S531) from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000
Description: A competitive ELISA for quantitative measurement of Rat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey CD97 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
